DawgTalkers.net Forums DawgTalk Palus Politicus Covid ~ Wave After Wave ~ Part 5

Not with mRNA vaccines -- though this can be a concern with adenovirus-based vaccinations (like J&J and AstraZeneca).

In those cases - the vaccine is made by taking an adenovirus (which is a family of viruses that can infect cells - but rarely cause serious illness). But then they modify that virus so that instead of producing more viruses once it infects a cell (like a normal virus) - it instead produces the spike protein for Covid. The cell then releases those spike proteins, which get detected by the immune system -- and the immune system attacks them and then produces long-lived antibodies to detect the Covid spike protein and destroy it in the future.

You can run the risk -- if you have lots of adenovirus based vaccines -- that your body will start mounting an effective defense to the original adenovirus before it has a chance to enter your cells -- meaning that your body kills the adenovirus **before** it can can produce the spike proteins that the vaccine was designed to produce. This usually isn't a huge concern (the injection has tons of adenovirus in it -- and some of it should escape your immune system and make it into cells) - but it's potentially a concern.

The mRNA vaccines don't use any virus. They inject mRNA -- which is a cellular instruction code -- which tells your cells how to make spike proteins. Your cells then make spike-proteins (like in the adenovirus case) and release them - and your immune system then attacks those spike proteins, giving you an antibody response.

The difference here - is that mRNA is not often found outside cells because it breaks down super quickly -- and is not something your immune system attacks. So your immune response won't break down the mRNA before it gets into cells and tells them to make spike proteins.



This part won't really happen - if your immune system is functioning -- and it sees an unusual protein -- it will attack it, and then build antibodies capable of detecting it and killing it in the future. There is probably a bit of the opposite effect -- for 3rd/4th/5th vaccinations -- you will probably be *super-protected** for the first week or two after the vaccination - because your immune system will respond to the latest vaccine by producing more "covid-killing antibodies" and they will be floating through your body for the next week or two in large numbers.



Potentially - and this is the major concern that affects how vaccines are made. The size of the Covid-19 virus is 30 kb (30,000 base pairs long long -- there are ~4 base pairs, and sets of 3 of them code for the ~20 nucleic acids that make up viruses (and cells). This specific sequence of 30,000 of them is the code that tells Covid how to enter human cells and then how to replicate to make more of itself, and escape from the cell).

This may seem crazy (it's like a 30 kilobit computer virus, essentially -- very small and very good at replicating itself). However, it's actually mostly junk -- most of the 30,000 nucleic acids don't do anything, they are just along for the ride.

The spike protein is the part that unlocks cells that it comes into contact with (specifically, it bonds to ACE-2 receptors that lie on the surface of human (and many animal) cells - and tells them to open the cell.) The spike protein is only 3000 base pairs long (so roughly 1/10 of the virus).


So why do Pfizer, Moderna (and also J&J and AstraZeneca) chose to build a vaccine for that specific part of the virus? In theory, you could build a vaccine that includes the protein structure of **any** part of the 30,000 bases in Covid - and that would cause your immune system to recognize that part and attack it.

However, because most of those sections of the virus don't *do* anything -- random mutations can significantly change those parts of the virus without affecting its ability to enter human cells and infect them. If you built a vaccine that attacked a random non-functional part of the virus, some virus particles would mutate in that region, the mutated viruses would avoid the vaccine - and then they would continue to spread.

Viruses actually mutate constantly - any person who has Covid probably has thousands of different random mutations in their body at any one time. The good news is that most mutations don't do anything -- because those parts of the virus are inactive.

However, certain regions - like the spike protein -- have to be exactly right. They have to connect on an atomic level to the ACE-2 receptor, and tell it to open up the cell. These are called "highly conserved regions" of a virus -- because any mutation in those regions will break the virus and make it unable to propagate. That is why the vaccine targets that region -- because if the virus tries to mutate in that region -- it probably won't be able to infect cells anymore.

The few mutations we've seen (Alpha, Beta, Delta, etc.) are the rare exceptions to that rule. 99.99999% of the mutations in the spike protein make the virus **worse** at infecting human cells. But a few of them potentially make the virus **better** at infecting cells.

For example, the Delta variant is defined as:

"The Delta variant has mutations in the gene encoding the SARS-CoV-2 spike protein[6] causing the substitutions D614G, T478K, P681R and L452R."

which means that (starting from some zero position) the 614th base pair is switched from "D" (the nucleic acid Aspartic Acid) to "G" (Glynine), the base pair at position 478 has switched from (T) threonine to (K) lysine, then there are switches of specific acids at positions 681 and 452 as well. This happens to be a good solution - it makes the virus better at infecting human cells.

There are a couple other "conserved regions" that you could build a vaccine to target. There's a specific region that helps code the outer membrane of the virus that prevents it from breaking down immediately when it exits an infected persons body, for example. In theory you could get a booster shot that targets a different virus region - to have a more resilient protection against variations in the spike protein.

One interesting sidenote - is that when you get an actual Covid infection -- you do get antibodies to every random part of the virus that exists (your immune system doesn't actually know **where** the spike protein of the virus is -- it just produces antibodies to every part of the virus it finds). This would allow a test to determine whether you actually got Covid, or had antibodies due to vaccinations (most tests just look at the spike protein though -- so they don't differentiate the two).

This also affects how your immune system will work for subsequent exposures. People who had covid will have an immune response that targets every part of the virus. People who had the vaccine will have an immune response that only targets the spike protein. However, the vaccine tends to produce a much much **stronger** response to the spike protein than previously infected people. The antibody response to spike proteins is around 10x larger for vaccinated people, than for people who previously got sick. This is probably why vaccines seem to offer better protection than previous illness.

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I vastly oversimplified the workings of the immune system above -- because I don't think it is that important to the main point. But there are lots of different details (antibodies, t-cells, b-cells, etc.) that all play different roles in how the immune system targets Covid.

The key is that the vaccine produces a very strong immune response specific to the spike protein, while infection produces a moderately strong response to many different parts of the virus.

That's about it.

j/c

So, Fauci is married to Christine Grady? The head of the NIH? Is that correct? Seems to me, IF that is correct, there ought to be a little investigation going on. Fauci was touting the vaccine, which is a good thing, but he's a stock holder..........conflict of interest anyone?

They were marked as a covid death which was 100% not the case. They died from the bullets going thru their head leg and chest.

Sorry for the losses around you.
That said, the overall numbers don’t lie. This is from the Oregon Health Science University hospital.

"your immune system will respond to the latest vaccine by producing more "covid-killing antibodies" and they will be floating through your body for the next week or two in large numbers."

Along with the tracking nano-bots?

j/c

So, Fauci is married to Christine Grady? The head of the NIH? Is that correct? Seems to me, IF that is correct, there ought to be a little investigation going on. Fauci was touting the vaccine, which is a good thing, but he's a stock holder..........conflict of interest anyone?

Anyway, check out Christine Grady, her husband, and what she's in charge of. Make your own opinions.

That probably didn't happen. And if it was reported that way initially, it would have been corrected later.

Then that medical examiner should lose their license.

For what? My understanding is they had the antibodies and were marked as with covid.

Do you have a specific charge or claim to make, or are you just throwing stuff out there like the Q folks?

Your understanding is incorrect. If a medical examiner is marking the cause of death incorrectly there are ramifications for them.

Apologies as I didn't mean to offend and I had you confused with SuperBrown for some reason, and that poster has littered the forums with lies.

As pointed out - the incorrect designation of death has happened all across the USA in fatalities from murder to car crashes. It appears to happen in very very low numbers but more often than anyone would expect - and it seems to be something that gets caught and updated.

There has been (still is) a campaign by some to suggest deaths from covid are grossly inflated, and false claims than any and all deaths are instantly attributed to Covid. That was probably another reason why I was too blunt in my response ... in reality if anyone cares to review statistics and excess mortality rates (globally or individual countries) - it points firmly to deaths from coivd being undercounted.

"your immune system will respond to the latest vaccine by producing more "covid-killing antibodies" and they will be floating through your body for the next week or two in large numbers."

Along with the tracking nano-bots?

"your immune system will respond to the latest vaccine by producing NO covid-killing antibodies" The vaccine will weaken your already compromised immune system from the first 2 shots until you ultimately die.

Have you ever taken an I.Q. test? There may be help for you out there that you qualify for.

I’m now able to fly, though I have to flap my arms like a bird to do it… so I look kind of ridiculous…but I can shoot cool blue lasers out of my eyes

Unfortunately my blue laser only shines out of my butt. But it is a helluva party trick.