Any pick after 111, Historically doesn't amount to, well the drop off in the reliablility to find in any way a productive player who will hang around and benefit your team, is so steep, that even though a handful can be found, there is almost no reason to put any merit in relying on players picked there, to be any good.
Tom Brady, Bo Jackson, Deacon Jones, Mike Webster, Bart Starr, Terrell Davis, Matt Birk, Brian Sipe, Adalius Thomas, Joe Horn, Robert Mathis, Ryan Fitzpatrick ... all picked 5th round or lower. Its not typically the case, but it does happen that lower round picks make big contributions.