Steelers have one of the best pass rushes (I think they lead the league in sacks) and the Browns 0-line is their biggest weakness. We saw what played out against the 49ers and the Titans and what Donald was able to do to us in the Rams game.
It's going to be a real challenge for the Browns because the pass rush is going to take away the deep passing game, so the offense needs to stay out of 3rd and long situations, they need to run the ball effectively, and the RPO and short passing game needs to be tight.
If the defense can create some turnovers, the Browns have an excellent shot, but the Steelers line is much better at protecting their QB.